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Organic compounds in which a hydrogen atom or more has been replaced by a halogen atom in an alkane molecule (saturated hydrocarbon chain). Halogen atoms include bromine, chlorine, fluorine, and iodine. Compounds may be in closed ring configurations.
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BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. It is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).
Orally bioavailable.
Highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE).
IC50 of 20 nM for HNE.
Nominated as a chemical probe via the Structural Genomics Consortium (SGC).
Ki value for MNE is 700 nM.
4th generation inhibitor of HNE.
More than 2,000-fold selectivity in a panel of 21 serine proteases.
Reveals significant efficacy in preclinical models of ALI and lung emphysema, demonstrating anti-inflammatory and anti-remodeling mode of action.
Shown significant beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice.
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X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) (IC50=0.61 nM). It is a less potent inhibitor of MET (IC50=0.69 nM) and displays potent anti-tumor activity.
Potent and highly specific ALK tyrosine kinase inhibitor
Less potent inhibitor of MET
Displays potent anti-tumor activity
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GluN1 (356-385) is an antigenic peptide against N-methyl-D-aspartate receptor (NMDAR) encephalitis. It reduces the density of surface NMDAR clusters in hippocampal neurons and can be used to study the pathogenesis of anti-NMDAR encephalitis.
Antigenic peptide against NMDAR encephalitis
Reduces density of surface NMDAR clusters in hippocampal neurons
Used to study pathogenesis of anti-NMDAR encephalitis
Related to peptide and derivatives, and peptide epitopes
Applicable to neurological, eye or ear disease
Associated with membrane transporter/ion channel, neuronal signaling, and iGluR pathways
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Perfluorohexanoic acid (Undecafluorocaproic acid) is a biological molecule intended for research use only. It is not for sale to patients. This substance appears solid below 12 °C and liquid above 14 °C, with a colorless to off-white appearance.
Biological molecule
Biochemical assay reagent control
For research use only
Colorless to off-white appearance
Solid below 12 °C, liquid above 14 °C
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